While a featured writer at Slash magazine in 1977, Chris D. formed a band with several friends from the Los Angeles punk scene, including Tito Larriva. The second album, "A Minute to Pray, A Second to Die", recorded and released in 1981, featured: John Doe, DJ Bonebrake (X), Dave Alvin (The Blasters), Bill Bateman (The Blasters) and Steve Berlin (The Blasters, Los Lobos). There were two more albums "Forever Came Today" (1982) and "A Hard Road to Follow" (1983) with another line-up (Don Kirk on guitar, Robyn Jameson on bass and Chris Wahl on drums as well Chris D. on vocals and occasionally Jill Jordan on backing vocals).
Chris D. worked as an A&R and in-house producer for Slash and Ruby Records from 1980 through the Spring of 1984. As well as acting as producer on all The Flesh Eaters albums, he also co-produced the debut album of The Gun Club, "Fire of Love", with Tito Larriva in 1982. He produced debut albums of The Dream Syndicate ("Days of Wine and Roses"'), Green On Red ("Gravity Talks"') and The Lazy Cowgirls. He remixed The Misfits' LP "Walk Among Us" with Glenn Danzig and The Germs' "What We Do is Secret" with Pat Smear.
In between his stints with The Flesh Eaters in the 1980s, Desjardins was the co-leader (with then-spouse Julie Christensen) of The Divine Horsemen (1984-1988).
In early 2006 it was announced he would be appearing for several dates in California and one date in London with John Doe, DJ Bonebrake, Dave Alvin, Bill Bateman, and Steve Berlin as The Flesh Eaters. This lineup had not performed together publicly since 1981.
Desjardins also issued a solo semi-acoustic LP on America's Enigma Records and the French New Rose label, "Time Stands Still" by Chris D./Divine Horseman in 1984, later released in Australia by Dog Meat Records of Melbourne. It features many old friends as guest musicians, including John Doe, Jeffrey Lee Pierce, Linda "Tex" Jones and Dave Alvin
Desjardins issued a second, rockier solo effort entitled "I Pass for Human" as Stone By Stone - basically a paean of loss[dubious – discuss] following the breakup with his wife and partner in The Divine Horsemen, Julie Christensen. It is a harrowing[who?] piece of work, reflecting on his life, his loves, and his at-that-time ongoing battle with heroin addiction. He released yet another one-off solo album "Love Cannot Die" through the Sympathy for the Record Industry label in 1995.
Between 1989 - 1993 and 1997 - 2000, Desjardins performed live with varying line-ups of The Flesh Eaters. Two Flesh Eaters albums have been released since 1999: "Ashes of Time" (1999) and "Miss Muerte" (2004) (the latter -- and so far, most recent -- effort was not supported by live gigs and was totally gestated and created in the studio).